Novo Nordisk’s Weight-Loss Drug CagriSema Shows Positive Blood Sugar Outcomes Despite Mild Side Effects

Novo Nordisk unveiled the full results of two Phase 3 trials for its experimental obesity and diabetes treatment, CagriSema, at the American Diabetes Association’s annual meeting in Chicago. The 68-week trials confirmed up to 23% weight loss in obese adults and 16% in overweight type 2 diabetics, with notable improvements in blood sugar levels.

Key Data:

• Glycated hemoglobin ≤6.5%: Achieved by 73.5% of patients on CagriSema vs. 15.9% on placebo

• GI-related side effects: Reported by 79.6% of patients on CagriSema (mostly mild to moderate)

• Serious adverse events: 9.8% in the CagriSema group vs. 6.1% in placebo

• Dropouts due to side effects: 6% for CagriSema vs. 3.7% for placebo

Despite initial investor disappointment over topline results last month—which contributed to the CEO's departure—the detailed findings may renew confidence in the drug’s metabolic benefits and regulatory potential.

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